Downstream Processing and Formulation

Efficient downstream processing (DSP) is essential for cost-effective biologics production. Current methods for purifying spike proteins, virus-like particles (VLPs), and plasmid DNA (pDNA) face scalability and separation challenges.

This strand will apply a systematic, data-driven approach—combining high-throughput screening, design of experiments (DOE), and AI-based analysis—to identify optimal purification strategies.

The team will also explore integrated capture technologies and develop stable formulations using preformulated media libraries, accelerating the path to clinical-grade biologics in collaboration with NRC and industry partners.